The perform of SIK1 in tumorigenesis. SIK1 is usually a tumor suppressor gene, which plays a vital regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 might also boost… Read More